Perbandingan Faktor Pertumbuhan dan Sitokin Air Susu Ibu (ASI) Neonatus Prematur dengan Neonatus Aterm

Authors

  • Anik Puryatni Medical Faculty, Brawijaya University
  • Prasetya Ismail Permadi Medical Faculty, Brawijaya University

DOI:

https://doi.org/10.21776/ub.ijhn.2021.008.01.5

Keywords:

breast milk, growth factors, cytokines, neonate

Abstract

Air Susu Ibu (ASI) mengandung berbagai komponen biologis aktif, yang berfungsi sebagai nutrisi, maturasi saluran cerna, dan pertahanan saluran pencernaan neonatus. Peran ASI dalam pertahanan (barrier) saluran pencernaan, diperankan oleh growth factors dan sitokin. Penelitian ini bertujuan untuk mengetahui perbedaan kadar faktor pertumbuhan dan sitokin ASI menurut kelompok usia kehamilan neonatus dan jenis tahapan ASI. Penelitian menggunakan desain deskriptif analitik, dengan metode potong lintang dengan consecutive sampling. Sampel dibagi menjadi empat kelompok yakni kelompok neonatus extremely preterm (n=6), very preterm (n=6), mild preterm (n=6), dan kelompok neonatus aterm (n=6). Dilakukan pengukuran kadar faktor pertumbuhan dan sitokin dari sampel ASI kolostrum (hari ke-3 pasca persalinan) dan ASI transisi (hari ke-10 pasca persalinan). Hasil penelitian menunjukkan bahwa kadar IGF-1 (p=0,05), EGF, hBD-1, hBD-2 dan IL-8 (p=0,00) berbeda bermakna antar kelompok penelitian. Kadar IGF-1 (p=0,03), EGF (p=0,00), dan hBD-1 (p=0,02) berbeda bermakna antara ASI kolostrum dan ASI transisi. Maka dapat disimpulkan berdasarkan hasil penelitian ini terdapat perbedaan kadar faktor pertumbuhan IGF-1, EGF dan hBD-1 antara neonatus prematur dan aterm berdasarkan jenis tahapan ASI

Author Biographies

Anik Puryatni, Medical Faculty, Brawijaya University

Nutrition and Metabolic Division, Department of Pediatric

Prasetya Ismail Permadi, Medical Faculty, Brawijaya University

Nutrition and Metabolic Division, Department of Pediatric

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Published

2021-07-31

How to Cite

1.
Puryatni A, Permadi PI. Perbandingan Faktor Pertumbuhan dan Sitokin Air Susu Ibu (ASI) Neonatus Prematur dengan Neonatus Aterm. IJHN [Internet]. 2021 Jul. 31 [cited 2024 Apr. 23];8(1):46-54. Available from: https://ijhn.ub.ac.id/index.php/ijhn/article/view/426

Issue

Vol. 8 No. 1 (2021)

Section

Articles

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