Beras Analog dapat Mencegah Kerusakan Ginjal pada Tikus Induksi Kombinasi HFD dan STZ

Authors

  • Hairrudin Hairrudin Fakultas Kedokteran Universitas Jember
  • Prajesiaji Praba Kumara
  • Rena Normasari

DOI:

https://doi.org/10.21776/ub.ijhn.2021.008.01.2

Keywords:

diabetes mellitus, streptozotocin, glomerulosklerosis, tubulus, beras analog

Abstract

Pengaturan diet pada diabetes mellitus (DM) dibutuhkan untuk mengendalikan kadar glukosa darah dan mencegah terjadinya komplikasi pada ginjal. Beras analog merupakan beras tiruan yang dibuat dari bahan pangan nonberas atau campuran dengan beras melalui teknik tertentu sehingga menyerupai beras. Beras analog diperkirakan dapat memperbaiki pengendalian kadar glukosa dan mencegah kerusakan ginjal karena memiliki kandungan serat dan resistant starch (RS) yang tinggi. Penelitian ini bertujuan untuk mengetahui efek beras analog dalam mencegah kerusakan ginjal pada tikus DM. Penelitian eksperimental ini menggunakan sampel ginjal tikus Wistar. Tikus dikelompokkan menjadi 4 kelompok (n=24), yaitu: kelompok kontrol (K0) dan tiga kelompok perlakuan (P). Kelompok K0 diberi pelet standar selama penelitian. Kelompok perlakuan diberi diet tinggi lemak selama 40 hari dan diiduksi streptozotocin (STZ) dosis 35 mg/kgBB pada hari ke-33. Hari ke-40 kelompok perlakuan dibagi menjadi 3 kelompok masing-masing diberi diet beras (PB), diet beras analog 1 (PBA1), dan diet beras analog 2 (PBA2) selama 3 minggu. Kerusakan ginjal diamati melalui gambaran histopatologi ginjal dan dinilai menggunakan sistem skoring berdasarkan tingkat glomerulosklerosis dan kerusakan tubulus. Hasil penelitian menunjukkan median skor glomerulosklerosis dan kerusakan tubulus pada K0=0,5 dan 1,0; PB=3,0 dan 4,0; PBA1=1,0 dan 2,5; PBA2=2,0 dan 3,0. Terdapat perbedaan signifikan (p<0,05) antara kelompok PB dengan PBA1 dan PBA2. Kesimpulannya adalah beras analog dapat mencegah kerusakan ginjal pada tikus DM

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Published

2021-07-31

How to Cite

1.
Hairrudin H, Kumara PP, Normasari R. Beras Analog dapat Mencegah Kerusakan Ginjal pada Tikus Induksi Kombinasi HFD dan STZ. IJHN [Internet]. 2021 Jul. 31 [cited 2024 Apr. 27];8(1):8-20. Available from: https://ijhn.ub.ac.id/index.php/ijhn/article/view/381

Issue

Vol. 8 No. 1 (2021)

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Creative Commons License
This work is licensed under a
Creative Commons Attribution-NonCommercial 4.0 International License