Tepung Pisang Berlin Unripe Meningkatkan Fungsi Kognitif Tikus Yang Diinduksi High Fat Diet

Authors

  • Ratih Putri Damayati Gizi Klinik, JurusanKesehatan, Politeknik Negeri Jember, Jawa Timur Indonesia
  • Firda Agustin Gizi Klinik, JurusanKesehatan, Politeknik Negeri Jember, Jawa Timur Indonesia
  • Ayu Febriyatna Gizi Klinik, JurusanKesehatan, Politeknik Negeri Jember, Jawa Timur Indonesia

DOI:

https://doi.org/10.21776/ub.ijhn.2020.007.02.1

Keywords:

Cognitive, HFD, UBF

Abstract

ABSTRAK

Konsumsi lemak yang berlebih berdampak pada ketidakseimbangan sistem saraf utamanya pada otak. Pisang  berlin unripe atau unripe banana flour (UBF) mengandung magnesium dan flavonoid. Tujuan penelitian yakni untuk mengetahui pengaruh tepung pisang berlin unripe terhadap fungsi kognitif tikus yang diinduksi HFD. Tikus wistar sebanyak 18 ekor dikelompokkan menjadi kelompok tikus normal (K-), kelompok tikus yang diinduksi HFD (K+), dan tikus yang diinduksi HFD+UBF. HFD diinduksi selama 9 minggu dan intervensi UBF diberikan selama empat minggu. Parameter yang diuji yakni kandungan pakan HFD+UBF fungsi kognitif tikus setelah diinduksi HFD (Pretest) dan setelah intervensi UBF (Postest). Pengukuran fungsi kognitif dengan menggunakan labirin. Hasil penelitian menunjukkan bahwa tikus yang diinduksi HFD setelah diberi UBF (posttest) mengalami peningkatan fungsi kognitif dibandingkan sebelum diberi perlakuan UBF (pretest)  (P<0,05). Simpulan diperoleh bahwa tepung pisang berlin unripe mampu memperbaiki fungsi kognitif tikus yang diinduksi HFD.

 

Kata kunci: HFD, Kognitif, UBF

 

ABSTRACT

Excessive consumption of a high-fat diet develops nervous system imbalance, particularly in the brain. Unripe banana flour (UBF) from berlin banana has magnesium and flavonoid content. This research aimed to determine the effect of unripe berlin banana flour on the cognitive function of rats induced with HFD. As many as eighteen white male Wistar rats were divided into normal rats group (K-), HFD-induced rats group (K+), and UBF+HFD-induced rats group. HFD induction was carried out for nine weeks, and UBF intervention was given for four weeks. The parameters tested were HFD+UBF feed content and the cognitive function of rats after HFD induction (Pretest) and after the UBF intervention (Postest). The cognitive function measurement was done using a maze. The results showed that HFD induced rats given UBF (posttest) had increased cognitive function compared to rats before treated with UBF (pretest) (P <0.05). In short, unripe berlin banana flour could improve the cognitive function of HFD-induced rats.

Keywords: Cognitive, HFD, UBF

References

  • Kementerian Kesehatan RI. Riset Kesehatan Dasar (Riskesdas). Jakarta: Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI; 2019.
  • Duan Y, Zeng L, Zheng C, Song B, Li F, Kong X, Xu K. Inflammatory Links Between High Fat Diets and Diseases. Frontiers in Immunology. 2018; 9(2649):1-10.
  • Duffy CM, Hofmeister JJ, Nixon JP, Butterick TA. High Fat Diet Increases Cognitive Decline And Neuroinflammation In A Model Of Orexin Loss. Neurobiology of Learning and Memory. 2019; 157: 41–47.
  • Fortune NC, Harville EW, Guralnik JM, Gustat J, Chen W, Qi L, Bazzano LA. Dietary Inake nd Cognitive Function: Evidence From The Boglusa Heart Study. Am J Clin Nutr. 2019;109(6):1656-1663.
  • Hapsari L, Masrum A. Keragaman dan Karakteristik Pisang (Musa acuminata) Kultivar Group Diploid A Koleksi Kebun Raya Purwodadi. Seminar Nasional HUT Kebun Raya Cibodas ke 159. 2011;225-229.
  • Febriyatna A, Damayati RP, Agustin F.
  • Analyze of Nutrition and Bioactive Compound in Unripe and Ripe Berlin Banana (Musa Acuminate) Flour. The First International Conference of Food and Agriculture. 2018; 616-618.
  • Heo HJ, Choi SJ, Choi SG, Shin DH, Lee JM, Lee CY. Effects of Banana, Orange, and Apple on Oxidative Stres –Induced Neurotoxicity in PC12 Cell. J Food Sci. 2008; 73(2):28-32.
  • Slutsky I, Abumaria N, Wu LJ, Huang C, Zhang L, Li B, ZhaoX, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G. Enhancement Of Learning And Memory By Elevating Brain Magnesium. Neuron. 2010;65(2):165-177.
  • Spencer JPE. The Interactions Of Flavonoids Within Neuronal Signalling Pathways. Genes Nutr. 2007; 2:257-273.
  • Badan Pusat Statistik. Produksi Sayuran Dan Buah-Buahan Tahunan Di Jawa Timur Tahun 2008-2016. 2018. www.jatim.bps.go.id. Diakses pada 27 April 2018.
  • Badan Pusat Statistik. Konsumsi Buah Dan Sayur Susenas Maret 2017. 2017. www.gizi.depkes.go.id. Diakses pada 27 April 2018.
  • Putri TK, Veronika D, Ismail A, Kurniawan A, Maxiselly Y, Irwan AW, Sutari W. Pemanfaatan Jenis-Jenis Pisang (Banana Dan Plantain) Lokal Jawa Barat Berbasis Produk Sale Dan Tepung. Jurnal Kultivasi. 2015; 14(2):63-70.
  • Kridawati A. Perbedaan Pengaruh Tepung Tempe Dan Tepung Tahu Terhadap Estrogen Serum, Betaamiloid Serum Dan Fungsi Kognitif Pada Tikus Betina Dengan Ovariektomi[Desertasi].Bogor (ID): Institut Pertanian Bogor; 2013.
  • Mirza I. Pengaruh Penggunaan Ekstrak Daun Pegagan (Centella asiatica(L.) Urban) Terhadap Fungsi Kognitif Tikus [Desertasi]. Bogor (ID): Institut Pertanian Bogor; 2012.
  • Febriyatna A, Damayati RP, Agustin F. The Effect Of High Fat Diet (HFD) Of HDL Cholesterol Level And Body Weight On Male White Wistar Rats. Proceeding of the 2nd International Conference on Food and Agriculture. 2019; 74-78
  • Restuti ANS, Yulianti A, Nuraini N. Effect of Modification Diet on The Body Weight of Sprague dawley Rats. Proceeding of the 1st International Conference on Food and Agriculture. 2018; 583-586.
  • Mergenthaler P, Lindauer U, Dienel GA, Meisel A. Sugar For The Brain: The Role Of Glucose In Physiological And Pathological Brain Function.Trends in Neurosciences. 2013; 30(10):1-11.
  • Sidhu JS, Zafar TA. Bioactive Compounds In Banana Fruits And Their Health Benefits. Food Quality and Safety. 2018; 2(4):183-188.
  • Samra RA. Fat and Satiety. In: Montmayeur JP, le Coutre J, editors. Fat Detection: Taste, Texture, and Post Ingestive Effect. Bona Raton(FL):CRC Press/Taylor&Francis, 2010. Chapter 15.
  • Freeman LR, Haley-Zitlin V, Rosenberger DS, Granholm AC. Damaging Effects Of A High-Fat Diet To The Brain And Cognition: A Review Of Proposed Mechanisms. Nutr Neurosci. 2014; 17(6): 241–251.
  • Yamanaka R, Shindo Y, Oka K.Magnesium Is a Key Player in Neuronal Maturation and Neuropathology. Int J Mol Sci. 2019; 20(14):1-26
  • Faryadi Q. The Magnificent Effect of Magnesium to Human Health: A Critical Review. International Journal of Applied Science and Technology. 2012; 2(3):118-126.
  • Li W, Yu J, Liu Y, Huang X, Abumaria N, Zhu Y, Huang X, Xiong W, Ren C, Liu XG, Chui D, Liu G. Elevation Of Brain Magnesium Prevents Synaptic Loss And Reverses Cognitive Deficits In Alzheimer'sDisease Mouse Model. Mol Brain.2014; 7(1):65.
  • Xu Z, Li L, Bao J, Zeng J, Li E, Magnesium Protects Cognitive Functions and Synaptic Plasticity in Streptozotocin-Induced Sporadic Alzheimer’s Model. 2014; 9(9): 1-11.
  • El Baza F, AlShahawi HA, Zahra S, Abdelhakim RA. Magnesium Supplementation In Children With Attention Deficit Hyperactivity Disorder. Egyptian Journal of Medical Human Genetics. 2016; 17(1):63-70.
  • Spencer JPE. The Impact Of Fruit Flavonoids On Memory And Cognition. British Journal of Nutrition. 2010; 104:S40-S47

Downloads

Published

2020-12-30

How to Cite

1.
Damayati RP, Agustin F, Febriyatna A. Tepung Pisang Berlin Unripe Meningkatkan Fungsi Kognitif Tikus Yang Diinduksi High Fat Diet. IJHN [Internet]. 2020 Dec. 30 [cited 2024 Apr. 24];7(2):84-91. Available from: https://ijhn.ub.ac.id/index.php/ijhn/article/view/351

Issue

Vol. 7 No. 2 (2020)

Section

Articles

License

Creative Commons License
This work is licensed under a
Creative Commons Attribution-NonCommercial 4.0 International License