Effect of Energy Restriction on Malondialdehyde Levels in Rats

Authors

  • Andi millaty Halifah Dirgahayu Concentration on Aging and Regenerative Medicine, Postgraduate Program in Biomedical Sciences, Graduate School of Hasanuddin University, Makassar, South Sulawesi
  • Aminuddin Aminuddin Departement of Clinical Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi
  • Arif Santoso Departement of Pulmonology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi
  • Nurpudji Astuti Departement of Clinical Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi
  • Ika Yustisia Departemen Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi
  • Irfan Idris Departement of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi

DOI:

https://doi.org/10.21776/ub.ijhn.2023.010.01.6

Keywords:

Restriksi energi, Malondialdehid, Rattus Novergicus

Abstract

Elevated malondialdehyde (MDA) levels indicate the occurrence of cell membrane oxidation. Calorie restriction is known to extend life expectancy. This study aims to investigate the effect of calorie restriction on MDA levels in young and old rats. An experimental approach was employed using Rattus norvegicus Wistar strain as the experimental animals, with a pre-post-test control group design. A total of 28 white rats were included in this study and were divided into four groups. The control groups, Group A and Group B, received standard feed and unrestricted access to distilled water, while the treatment groups, Group C and Group D, were fed with a 40% reduction in calorie intake and distilled water. Data analysis was performed using SPSS 21.0 (SPSS, Inc., Chicago, IL) with a 0.05 significance level. The results showed a difference in MDA level changes between group B (control group) and group D (treatment group) (p<0.05). This study concludes that MDA levels are higher in the elderly compared to young rats, and a 40% calorie restriction can reduce MDA levels.

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Published

2023-07-06

How to Cite

1.
Dirgahayu A millaty H, Aminuddin A, Santoso A, Astuti N, Yustisia I, Idris I. Effect of Energy Restriction on Malondialdehyde Levels in Rats. IJHN [Internet]. 2023 Jul. 6 [cited 2023 Dec. 6];10(1):51-8. Available from: https://ijhn.ub.ac.id/index.php/ijhn/article/view/612

Issue

Vol. 10 No. 1 (2023)

Section

Articles

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Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Creative Commons License
This work is licensed under a
Creative Commons Attribution-NonCommercial 4.0 International License

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